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KMID : 0923620100100040120
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Immune Network
2010 Volume.10 No. 4 p.120 ~ p.125
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T-Cell Dysfunction and Inhibitory Receptors in Hepatitis C Virus Infection
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Lee Ji-No
Suh William I.
Shin Eui-Cheol
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Abstract
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Dysfunction of the virus-specific T cells is a cardinal feature in chronic persistent viral infections such as one caused by hepatitis C virus (HCV). In chronic HCV infection, virus-specific dysfunctional CD8 T cells often overexpress various inhibitory receptors. Programmed cell death 1 (PD-1) was the first among these inhibitory receptors that were identified to be overexpressed in functionally impaired T cells. The roles of other inhibitory receptors such as cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) have also been demonstrated in T-cell dysfunctions that occur in chronic HCV patients. Blocking these inhibitory receptors in vitro restores the functions of HCV-specific CD8 T cells and allows enhanced proliferation, cytolytic activity and cytokine production. Therefore, the blockade of the inhibitory receptors is considered as a novel strategy for the treatment of chronic HCV infection.
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KEYWORD
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Hepatitis C virus, CD8 T cells, T-cell dysfunction, PD-1, CTLA-4, Tim-3
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